UKLS

The United Kingdom Lung Cancer Screening (UKLS) trial is investigating if lung cancer screening could be implemented in the UK, by combining the LLP lung cancer risk score and low dose CT imaging
(Field et al., Health Technol Assess 2016, 20(40):1-146; Field et al., Thorax 2016, 71(2):161-70).

www.ukls.org
       
Participants Information 

UKLS Publications

European position statement on lung cancer screening.
Oudkerk M, Devaraj A, Vliegenthart R, Henzler T, Prosch H, Heussel CP, Bastarrika G, Sverzellati N, Mascalchi M, Delorme S, Baldwin DR, Callister ME, Becker N, Heuvelmans MA, Rzyman W, Infante MV, Pastorino U, Pedersen JH, Paci E, Duffy SW, de Koning H, Field JK.
Lancet Oncol. 2017 Dec;18(12):e754-e766. doi: 10.1016/S1470-2045(17)30861-6. Review.
PMID: 29208441

 Impact of low-dose CT screening on smoking cessation among high-risk participants in the UK Lung Cancer Screening Trial.
Brain K, Carter B, Lifford KJ, Burke O, Devaraj A, Baldwin DR, Duffy S, Field JK.
Thorax. 2017 Oct;72(10):912-918. doi: 10.1136/thoraxjnl-2016-209690. Epub 2017 Jul 14.
PMID: 28710339

The impact of trained radiographers as concurrent readers on performance and reading time of experienced radiologists in the UK Lung Cancer Screening (UKLS) trial.

Nair A, Screaton NJ, Holemans JA, Jones D, Clements L, Barton B, Gartland N, Duffy SW, Baldwin DR, Field JK, Hansell DM, Devaraj A.
Eur Radiol. 2018 Jan;28(1):226-234. doi: 10.1007/s00330-017-4903-z. Epub 2017 Jun 22.
PMID: 28643093
416569

Risk assessment in relation to the detection of small pulmonary nodules.
Field JK, Marcus MW, Oudkerk M.
Transl Lung Cancer Res. 2017 Feb;6(1):35-41. doi: 10.21037/tlcr.2017.02.05. Review.
PMID: 28331822

The role of screening expectations in modifying short-term psychological responses to low-dose computed tomography lung cancer screening among high-risk individuals. Dunn CE, Edwards A, Carter B, Field JK, Brain K, Lifford KJ.
Patient Educ Couns. 2017 Feb 27. pii: S0738-3991(17)30115-5. doi: 10.1016/j.pec.2017.02.024. [Epub ahead of print]
PMID: 28274672

Optimum low dose CT screening interval for lung cancer: the answer from NELSON?
Baldwin DR, Duffy SW, Devaraj A, Field JK.
Thorax. 2017 Jan;72(1):6-7. doi: 10.1136/thoraxjnl-2016-209011. No abstract available.
PMID: 27974632

Implementation planning for lung cancer screening: five major challenges.
Field JK, Duffy SW, Devaraj A, Baldwin DR.
Lancet Respir Med. 2016 Sep;4(9):685-7. doi: 10.1016/S2213-2600(16)30233-8. No abstract available.
PMID: 27599242

Long-term psychosocial outcomes of low-dose CT screening: results of the UK Lung Cancer Screening randomised controlled trial.
Brain K, Lifford KJ, Carter B, Burke O, McRonald F, Devaraj A, Hansell DM, Baldwin D, Duffy SW,Field JK.
Thorax. 2016 Jul 28. pii: thoraxjnl-2016-208283. doi: 10.1136/thoraxjnl-2016-208283. [Epub ahead of print]
PMID: 27471048

 Comparing the performance of trained radiographers against experienced radiologists in the UK Lung Cancer Screening (UKLS) Trial.
Nair A, Gartland N, Barton B, Jones D, Clements L, Screaton NJ, Holemans JA, Duffy SW, Field JK, Baldwin DR, Hansell DM, Devaraj A.
Br J Radiol. 2016 Jul 27:20160301. [Epub ahead of print]
PMID: 27461068 

The UK Lung Cancer Screening Trial: a pilot randomised controlled trial of low-dose computed tomography screening for the early detection of lung cancer.
Field JK, Duffy SW, Baldwin DR, Brain KE, Devaraj A, Eisen T, Green BA, Holemans JA, Kavanagh T, Kerr KM, Ledson M, Lifford KJ, McRonald FE, Nair A, Page RD, Parmar MK, Rintoul RC, Screaton N, Wald NJ, Weller D, Whynes DK, Williamson PR, Yadegarfar G, Hansell DM.
Health Technol Assess. 2016 May;20(40):1-146. doi: 10.3310/hta20400.
PMID: 27224642

Incorporating epistasis interaction of genetic susceptibility single nucleotide polymorphisms in a lung cancer risk prediction model.
Marcus MW, Raji OY, Duffy SW, Young RP, Hopkins RJ, Field JK.
Int J Oncol. 2016 Jul;49(1):361-70. doi: 10.3892/ijo.2016.3499. Epub 2016 Apr 25
PMID: 27121382

Lung cancer CT screening: is annual screening necessary?
Field JK, Duffy SW.Lancet Oncol. 2016 Mar 18. pii: S1470-2045(16)00079-6. doi: 10.1016/S1470-2045(16)00079-6. [Epub ahead of print] No abstract available.
PMID: 27009071

CT screening for lung cancer: Is the evidence strong enough?
Field JK, Devaraj A, Duffy SW, Baldwin DR.
Lung Cancer. 2016 Jan;91:29-35. doi: 10.1016/j.lungcan.2015.11.003. Epub 2015 Nov 30. Review.
PMID: 26711931

UK Lung Cancer RCT Pilot Screening Trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening.
Field JK, Duffy SW, Baldwin DR, Whynes DK, Devaraj A, Brain KE, Eisen T, Gosney J, Green BA, Holemans JA, Kavanagh T, Kerr KM, Ledson M, Lifford KJ, McRonald FE, Nair A, Page RD, Parmar MK, Rassl DM, Rintoul RC, Screaton NJ, Wald NJ, Weller D, Williamson PR, Yadegarfar G, Hansell DM.
Thorax. 2016 Feb;71(2):161-70. doi: 10.1136/thoraxjnl-2015-207140. Epub 2015 Dec 8.
PMID: 26645413

Barriers to uptake among high-risk individuals declining participation in lung cancer screening: a mixed methods analysis of the UK Lung Cancer Screening (UKLS) trial. Ali N, Lifford KJ, Carter B, McRonald F, Yadegarfar G, Baldwin DR, Weller D, Hansell DM, Duffy SW,Field JK, Brain K.
BMJ Open. 2015 Jul 14;5(7):e008254. doi: 10.1136/bmjopen-2015-008254.

Lung cancer screening: identifying the high risk cohort.
Marcus MW, Raji OY, Field JK.
J Thorac Dis. 2015 Apr;7(Suppl 2):S156-62. doi: 10.3978/j.issn.2072-1439.2015.04.19.

Perspective: The screening imperative.
Field JK.
Nature. 2014 Sep 10;513(7517):S7. doi: 10.1038/513S7a

Lung cancer screening with low dose computed tomography.
Baldwin DR, Hansell DM, Duffy SW, Field JK.
BMJ. 2014 Mar 7;348:g1970. doi: 10.1136/bmj.g1970. 

MyLungRisk: a user-friendly, web-based calculator for risk assessment of lung cancer based on the validated Liverpool Lung Project risk prediction model.
Y ChenM W. MarcusA NiazS W. Duffy  J K. Field. International Journal of Health Promotion and Education  Published online: 25 Feb 2014 DOI: 10.1080/14635240.2014.888814.

Translation of research results to simple estimates of the likely effect of a lung cancer screening programme in the United Kingdom.
Duffy SW, Field JK, Allgood PC, Seigneurin A.
Br J Cancer. 2014 Feb 13. doi: 10.1038/bjc.2014.63. [Epub ahead of print]

The UK Lung Screen (UKLS): demographic profile of first 88,897 approaches provides recommendations for population screening.
McRonald FE, Yadegarfar G, Baldwin DR, Devaraj A, Brain KE, Eisen T, Holemans JA, Ledson M, Screaton NJ, Rintoul RC, Hands CJ, Lifford K, Whynes DK, Kerr KM, Page R, Parmar M, Wald N, Weller D, Williamson PR, Myles J, Hansell DM, Duffy SW, Field JK. Cancer Prev Res (Phila). 2014 Mar;7(3):362-71. doi: 10.1158/1940-6207.CAPR-13-0206. Epub 2014 Jan 17.

CT screening for lung cancer: countdown to implementation. 
F
ield JK,
Hansell DM, Duffy SW, Baldwin DR.  Lancet Oncol. 2013 Dec;14(13):e591-600. doi: 10.1016/S1470-2045(13)70293-6.

The contribution of risk prediction models to early detection of lung cancer.
Field JK, Chen Y, Marcus MW, McRonald FE, Raji OY, Duffy SW.
J Surg Oncol. 2013 Aug 29. doi: 10.1002/jso.23384. [Epub ahead of print]

Prospects for population screening and diagnosis of lung cancer.
Field JK, Oudkerk M, Pedersen JH, Duffy SW.
Lancet. 2013 Aug 24;382(9893):732-41. doi: 10.1016/S0140-6736(13)61614-1.

European randomized lung cancer screening trials: Post NLST.
Field JK, van Klaveren R, Pedersen JH, Pastorino U, Paci E, Becker N, Infante M, Oudkerk M, de Koning HJ; on behalf of the European Randomized Screening Trial Group.
J Surg Oncol. 2013 Jul 25. doi: 10.1002/jso.23383. [Epub ahead of print]

Measurement methods and algorithms for the management of solid nodules.
Nair A, Baldwin DR, Field JK, Hansell DM, Devaraj A.
J Thorac Imaging. 2012 Jul;27(4):230-9. doi: 10.1097/RTI.0b013e31824f83e1. Review.
PMID: 22695060 [PubMed - indexed for MEDLINE]

International Association for the Study of Lung Cancer Computed Tomography Screening Workshop 2011 report.
Field JK, Smith RA, Aberle DR, Oudkerk M, Baldwin DR, Yankelevitz D, Pedersen JH, Swanson SJ, Travis WD, Wisbuba II, Noguchi M, Mulshine JL; IASLC CT Screening Workshop 2011 Participants.
J Thorac Oncol. 2012 Jan;7(1):10-9. doi: 10.1097/JTO.0b013e31823c58ab.

CT screening for lung cancer in the UK: position statement by UKLS investigators following the NLST report.
Field JK, Baldwin D, Brain K, Devaraj A, Eisen T, Duffy SW, Hansell DM, Kerr K, Page R, Parmar M, Weller D, Williamson P, Whynes D; UKLS Team.
Thorax. 2011 Aug;66(8):736-7. doi: 10.1136/thoraxjnl-2011-200351. Epub 2011 Jul 1.

UK Lung Screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer.
Baldwin DR, Duffy SW, Wald NJ, Page R, Hansell DM, Field JK.
Thorax. 2011 Apr;66(4):308-13. doi: 10.1136/thx.2010.152066. Epub 2011 Feb 11.

 

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