Epidemiology

The Epidemiology group is led by Dr. Michael Marcus. Our primary objective is to conduct epidemiological and statistical research by developing and evaluating robust statistical models that integrates clinical, molecular and epidemiological characteristics to investigate causative factors and determinants of lung cancer.
Epidemiology is the study of the occurrence and distribution of health-related states or events in specified populations, including the study of the determinants influencing such states and the application of this knowledge to control health problems [1]. At the Roy Castle Lung Cancer Research Programme, the epidemiology group is involved in several projects locally – the Liverpool Lung Project (LLP), the Chinese LLP, Hospital Episode statistics (HES) project and two European projects CURELUNG and LCAOS and several national and international collaborations.
Lung cancer is the leading cause of cancer mortality worldwide with 1.6 million deaths each year and about 41,400 new diagnoses yearly in the United Kingdom. It is a serious public health problem. Our research activity provides support towards advancing the body of knowledge on early detection and prevention of lung cancer thereby improving patient survival. The group has conducted and/or participated in a variety of epidemiological research projects focusing on a wide range of themes including risk modelling [2-5], screening [6], diagnosis [7] meta-analysis [8,9] and genetic susceptibility [10]. Other responsibilities of this group include and are not limited to the provision of methodological advice in study design, data management, protocol development, statistical analysis and publication and dissemination of results.

References
1. Principles of Epidemiology in Public Health Practice, 3rd Edition
2. Cassidy A, Myles JP, van Tongeren M, et al. The LLP risk model: an individual risk prediction model for lung cancer. Br J Cancer. 2008;98:270-6.
3. Raji OY, Duffy SW, Agbaje OF et al. Predictive accuracy of the Liverpool Lung Project risk model for stratifying patients for computed tomography screening for lung cancer: a case-control and cohort validation study. Ann Intern Med 2012;157:242-50.
4. Marcus MW, Chen Y, Liloglou T, Field JK. New perspectives to respiratory tract cancers. Head Neck Oncol 2013;5(3):28.
5. Field JK, Ying C, Marcus MW, Raji OY, McRoland F, Duffy SW. The contribution of risk prediction models to early detection of lung cancer. J Surg Oncol 2013;108:304-11.
6. Baldwin DR, Duffy SW, Wald NJ, et al. UK lung Screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer. Thorax 2011;66:308-13.
7. Nikolaidis G, Raji OY, Markopoulou S, et al. DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer. Cancer Res 2012 ;72:5692-701.
8. Olsson AC, Xu Y, Schüz J, Vlaanderen J, Kromhout H, Vermeulen R, Peters S, Stücker I, Guida F, Brüske I, Wichmann H-E, Consonni D, Landi M T, Caporaso N, Tse LA, Yu IT, Siemiatycki J, Lavoué J, Mirabelli D, Richiardi L, Simonato L, Gustavsson P, Plato N, Jöckel K-H, Ahrens W, Pohlabeln H, Tardón A(16), Zaridze D, Marcus MW, ‘t Mannetje A , Pearce N , McLaughlin J, Demers P, Szeszenia-Dabrowska N , Lissowska J, Rudnai P, Fabianova E, Dumitru RS, Bencko V, Foretova L, Janout V , Boffetta P, Benhamou S, Fortes C, Bueno-de-Mesquita B, Kendzia B, Behrens T, Pesch B, Brüning T(, Straif K. Lung cancer risk among hairdressers – a pooled analysis of case-control studies conducted between 1985 and 2010. A J Epidemiol 2013;178:1355-65.
9. Kendzia B, Behrens T, Jöckel K-H, Siemiatycki J, Kromhout H, Vermeulen R, Peters S, van Gelder R, Olsson A, Brüske I, Wichmann H-E, Stücker I, Guida F, Tardón A, Merletti F, Mirabelli D, Richiardi L, Pohlabeln H, Ahrens W, Landi MT, Caporaso N, Consonni D, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Gustavsson P, Marcus MW, Fabianova E, ‘t Mannetje A, Pearce N, Tse S, Yu I, Rudnai P, Bencko V, Janout V, Mates D, Foretova L, Forastiere F, McLaughlin J, Demers P, Bueno-de-Mesquita B, Boffetta P, Schüz J, Straif K, Pesch B, Brüning T. Welding and lung cancer in a pooled analysis of case-control studies. A J Epidemiol 2013 [In press]. 
10. Gorlov IP, Meyer P, Liloglou T, et al. Seizure 6-like (SEZ6L) gene and risk for lung cancer. Cancer Res. 2007;67:8406-11.

CONTACTS

Professor John K. Field
Research Director

Tel:  0151 794 9113


J.K.Field@liverpool.ac.uk
Dr Triantafillos Liloglou
Lecturer, Biomarkers and Clinical Resources Group
Tel:  0151 794 9121

 

T.Liloglou@liverpool.ac.uk

Janet Farley (job share with Gaynor Hunt)
Study Co-ordinator

Tel:   0151 794 9107
   

farleyj@roycastle.liv.ac.uk
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